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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- Name N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- CAS 16357-59-8
- Purity 99%
Product Details
Manufacturer supply N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8 with sufficient stock and high standard
- Molecular Formula: C14H17NO3
- Molecular Weight: 247.294
- Appearance/Colour: White to pale yellow solid
- Vapor Pressure: 3.04E-05mmHg at 25°C
- Melting Point: 62-67 °C(lit.)
- Refractive Index: 1.564
- Boiling Point: 355.9 °C at 760 mmHg
- PKA: -1.27±0.40(Predicted)
- Flash Point: 169 °C
- PSA： 38.77000
- Density: 1.16 g/cm3
- LogP: 3.10390
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline(Cas 16357-59-8) Usage
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Purification Methods |
Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.] |
InChI:InChI=1/C14H17NO3/c1-3-17-13-10-9-11-7-5-6-8-12(11)15(13)14(16)18-4-2/h5-10,13H,3-4H2,1-2H3/t13-/m1/s1
16357-59-8 Relevant articles
A highly enantioselective Mannich reaction of aldehydes with cyclic N-acyliminium ions by synergistic catalysis
Berti, Francesco,Malossi, Federico,Marchetti, Fabio,Pineschi, Mauro
supporting information, p. 13694 - 13697 (2015/09/01)
Matched combinations of Bronsted or Lewi...
Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
-
, (2008/06/13)
Disclosed are compounds which inhibit β-...
Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
-
, (2008/06/13)
Disclosed are compounds which inhibit β-...
Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
-
, (2008/06/13)
Disclosed are compounds which inhibit β-...
16357-59-8 Process route
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91-22-5
quinoline
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64-17-5
ethanol
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541-41-3
chloroformic acid ethyl ester
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16357-59-8
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
| Conditions | Yield |
|---|---|
|
With
sodium hydrogencarbonate;
In
dichloromethane; water;
at 0 ℃;
for 1.33333h;
|
69%
|
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16357-59-8
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
| Conditions | Yield |
|---|---|
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Ether (V), Ethanol, BF3-Etherat;
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Ether (V) u. 2-Hydroxy-N-carbethoxy-1,2-dihydrochinolin-Gemisch (IV), Ethanol, BF3-Etherat;
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1-Ethoxycarbonyl-chinoliniumchlorid, A., BF3;
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Chinolin 1. Cl-CO-OCH2CH3, Dimethylformamid, KOH 2. Ethanol, BF3-Etherat;
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/BRN= 558800/ (III1), Ethanol, BF3-Etherat;
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Chinolin 1. Chlorkohlensaeure-ethylester, 0grad 2. Ethyl-diisopropyl-amin, Ethanol;
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Chinolin, Ethylchlorformiat, Diisopropyl-ethylamin, in A.;
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Chinolin 1. Chlorameisensaeure-ethylester, KOH 2. Ether*BF3, in A.;
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Chinolin, A., Chlorameisensaeure-ethylester;
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16357-59-8 Upstream products
-
91-22-5
quinoline
-
64-17-5
ethanol
-
541-41-3
chloroformic acid ethyl ester
16357-59-8 Downstream products
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3673-34-5
thiazole-2-ylcarbamic acid ethyl ester
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65638-93-9
N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid
-
27544-35-0
Cbz-L-Ala-L-Pro-Ot Bu
-
120791-82-4
N-(Ethoxycarbonyl)-L-prolin-tert-butylester
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