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nicotinic anhydride
- Name nicotinic anhydride
- CAS 16837-38-0
- Purity 99%
Product Details
Factory Sells Best Quality nicotinic anhydride 16837-38-0 with GMP standards
- Molecular Formula: C12H8N2O3
- Molecular Weight: 228.207
- Vapor Pressure: 5.25E-07mmHg at 25°C
- Melting Point: 124 °C
- Refractive Index: 1.599
- Boiling Point: 412.3 °C at 760 mmHg
- PKA: 2.51±0.10(Predicted)
- Flash Point: 203.1 °C
- PSA： 69.15000
- Density: 1.317 g/cm3
- LogP: 1.47380
nicotinic anhydride(Cas 16837-38-0) Usage
|
Synthesis Reference(s) |
Journal of the American Chemical Society, 69, p. 2231, 1947 DOI: 10.1021/ja01201a502 |
|
Preparation |
3-pyridine anhydride can be used as an organic reagent. |
InChI:InChI=1/C12H8N2O3/c15-11(9-3-1-5-13-7-9)17-12(16)10-4-2-6-14-8-10/h1-8H
16837-38-0 Relevant articles
-
Schrecker,Maury
, p. 5803 (1954)
-
-
Badgett
, p. 2231 (1947)
-
Niacin-ligated platinum(iv)-ruthenium(ii) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity: In vivo
Chen, Chao,Fang, Tao,Han, Weidong,Ren, Lulu,Shu, Liwei,Wang, Hangxiang,Wang, Yuchen,Ye, Zhijian
, p. 3069 - 3072 (2020)
Niacin-ligated platinum(iv)-ruthenium(ii...
Conformational Studies of N,N-Disubstituted Nicotinamides. NMR Peak Assignments and Utilization of Shift Reagents with 2,6-Dichloronicotinamides
Newkome, George R.,Kawato, Toshio
, p. 629 - 632 (1980)
Europium-induced shift studies are repor...
Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake
Cheng, Xi,Zhang, Da-Li,Li, Xiao-Bing,Ye, Jian-Tao,Shi, Lei,Huang, Zhi-Shu,Gu, Lian-Quan,An, Lin-Kun
, p. 24 - 30 (2014)
A series of diacyltanshinol derivatives ...
Isothiourea-Catalysed Regioselective Acylative Kinetic Resolution of Axially Chiral Biaryl Diols
Qu, Shen,Greenhalgh, Mark D.,Smith, Andrew D.
supporting information, p. 2816 - 2823 (2019/02/05)
An operationally simple isothiourea-cata...
Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance
Callies, Oliver,Sánchez-Ca?ete, María P.,Gamarro, Francisco,Jiménez, Ignacio A.,Castanys, Santiago,Bazzocchi, Isabel L.
supporting information, p. 1880 - 1890 (2016/03/22)
P-glycoprotein (P-gp) plays a crucial ro...
16837-38-0 Process route
-
-
59-67-6
nicotinic acid
-
-
16837-38-0
nicotinic anhydride
| Conditions | Yield |
|---|---|
|
With
bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
97%
|
|
nicotinic acid;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
With
bis(trichloromethyl) carbonate;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
97%
|
|
With
N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
|
96%
|
|
With
bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
|
90%
|
|
With
di-tert-butyl dicarbonate; triethylamine;
In
tetrahydrofuran;
|
85%
|
|
With
bis(trichloromethyl) carbonate; triethylamine;
In
benzene;
at 5 - 20 ℃;
Reflux;
|
68%
|
|
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 - 25 ℃;
|
44%
|
|
With
thionyl chloride; nitrobenzene;
at 210 ℃;
Behandeln des Reaktionsgemisches mit Kaliumnicotinat und erneuten Erhitzen auf 210grad;
|
|
|
With
thionyl chloride; 1,2-dichloro-benzene;
at 210 ℃;
Behandeln des Reaktionsgemisches mit Kaliumnicotinat und erneuten Erhitzen auf 210grad;
|
|
|
With
dacarbazine;
In
dichloromethane;
for 0.5h;
|
|
|
With
bis(trichloromethyl) carbonate; triethylamine;
In
benzene;
at 20 ℃;
for 0.75h;
|
6.35 g
|
|
With
2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate;
In
tetrahydrofuran;
for 0.0166667h;
|
|
|
With
thionyl chloride; triethylamine;
In
toluene;
at 0 - 60 ℃;
for 0.75h;
|
|
|
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Inert atmosphere;
|
-
-
20260-53-1
pyridine-3-carbonyl chloride hydrochloride
-
-
110-70-3
N,N`-dimethylethylenediamine
-
-
16837-38-0
nicotinic anhydride
-
-
72301-63-4
N,N'-Dimethyl-N,N'-ethylenebis(nicotinamide)
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 30 ℃;
for 30h;
|
52%
|
16837-38-0 Upstream products
-
59-67-6
nicotinic acid
-
10400-19-8
3-pyridinecarbonyl chloride
-
20260-53-1
pyridine-3-carbonyl chloride hydrochloride
-
110-70-3
N,N`-dimethylethylenediamine
16837-38-0 Downstream products
-
2139-47-1
nifenazone
-
111796-60-2
2,4-diphenyl-5-(pyridin-3-yl)oxazole
-
40061-64-1
2-hydroxy-2-phenyl-1-[3]pyridyl-ethanone
-
13425-39-3
etofylline nicotinate
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